A relatively new way of administration of therapeutic peptides and proteins (such as cytokines, domain antibodies, Fab fragments or single chain antibodies) is sublingual administration. Peptides and proteins are not stable in the gastro-intestinal tract, mainly due to degradation by enzymes and pH differences. As a consequence, most peptides (such as insulin, exenatide, vasopressin, etc...) or proteins (such as interferon, EPO and interleukins) have to be administered by injection. Recently, new technologies have allowed sublingual administration of such molecules. Increased efforts are underway to deliver macromolecules (peptides, proteins and immunotherapies) by sublingual route, by companies such as Novo Nordisk, Sanofi and BioLingus.
Most will find they will buy injectable steroids far more often than oral forms or any other form for that matter and most who do will find their cycles to be far more worthwhile than those who do not. Many who are unfamiliar with anabolic steroid use are often afraid of injectable forms; after all, sticking yourself with a needle does not sound too appealing. Even so, most will find the procedure to be fairly simple and generally painless and more often than not prior fear is laughed at once it’s discovered that the process truly is no big deal at all.
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