Another disadvantage is that all steroids (not only oral) inhibit hypothalamus-pituitary-testicular axis (HPTA) and endogenous testosterone production. For this reason, you should not take oral steroids solo. You probably know that almost all steroids are derived from our native androgen testosterone. However, these derivatives are no longer native to our body. Hence, testosterone shall always be used in stack with oral steroids to maintain normal physiological functions of the body during the cycle. Furthermore, as mentioned above, oral steroids have a feature to reduce SHBG levels, which means that the efficiency of testosterone stacked with tablets will raise significantly.
The adverse effects of corticosteroids in pediatric patients are similar to those in adults (see ADVERSE REACTIONS ). Like adults, pediatric patients should be carefully observed with frequent measurements of blood pressure, weight, height, intraocular pressure, and clinical evaluation for the presence of infection, psychosocial disturbances, thromboembolism, peptic ulcers, cataracts, and osteoporosis. Pediatric patients who are treated with corticosteroids by any route, including systemically administered corticosteroids, may experience a decrease in their growth velocity. This negative impact of corticosteroids on growth has been observed at low systemic doses and in the absence of laboratory evidence of HPA axis suppression (., cosyntropen stimulation and basal cortisol plasma levels). Growth velocity may therefore be a more sensitive indicator of systemic corticosteroid exposure in pediatric patients treated with corticosteroids should be monitored, and the potential growth effects of prolonged treatment should be weighed against clinical benefits obtained and the availability of treatment alternatives. In order to minimize the potential growth effects of corticosteroids, pediatric patients should be titrated to the lowest effective dose.