Alpinia galangal Linn. Zingiberaceae: In rats with adjuvant-induced arthritis, administration of galangin (5, 10, 20 mg/kg) and MEAO significantly ((P<) suppressed the paw swelling, increased the paw withdrawal latency, and reduced the paw thickness. Diclofenac was taken as standard. Galangin (20mg/kg) and MEAO inhibited the increased level of serum lysosomal enzyme activity viz. aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phophatase (ALP). Galangin, MEAO exhibited anti-arthritic activity by improving the altered haematological parameters.