Research shows that at least 2 grams of GABA should be taken for it to be effective. 5g is shown to be more effective, and the effectiveness of GABA is maxed out at 18 grams. There are studies done on GABA where it's administered either orally or intravenously. Taking GABA orally is not as effective as taking it intravenously; however it's more reflective of expected real world results, as most GABA supplements are designed to be taken orally. Despite this, GABA is effective even when taken orally.
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No, studies have shown that consumption of creatine monohydrate does not cause any serious adverse side effects. However, some people may experience slight stomach and digestive discomfort like gas or bloating or possibly diarrhea for a few weeks when first starting the use of creatine. The digestive and stomach problems may be eradicated by lowering the amount of intake of creatine monohydrate. Since creatine supplementation causes the muscles to retain water, some people may experience a slight weight gain of as many as five pounds in the first few weeks, and may also become dehydrated.